Genetic Modification of Animals

To be used for research activities including the generation of transgenic animals by breeding or the use of pre-generated genetically modified/engineered animals (GM animals). We cannot currently change the eProtocol application, and we are re-tasking sections of the application for our needs. Thus, in certain cases please ignore the question, and use the text boxes as needed.

Please ignore the red lettering on the eProtocol page that indicates that this section is only for rodents.

For the generation of GM animals not from breeding, please use the r/sNA section (2.) to describe the method(s) you will use (do not use 6.b).

For the generation of GM animals via breeding, please answer 6.a). Genotypes are not necessary to detail. Please consider the below requests for the use of those animals.

To account for only the use of existing GM animals in your application, please check “yes” for question 6.a) and include in the 6.a)i) text box - “EXISTING GE Animals - FOR USE ONLY”. In the text box for 6.a)ii) enter a general description of the phenotypes. The IBC admin may contact you for any clarifications. Please briefly describe, in the study objectives section 1.b), any experimental work with your GM animals from creation/receipt to disposal.

Regardless of the method of generation, it is likely you will use the GM animals after generation, which should be accounted for with the above procedure.

Please note that if GM animals are not administered any agents (r/sNA molecules, biological toxins, or infectious agents), then the Animal Housing Location in the Safety section 7a)ii of the application will not be activated.  Instead, please add your animal housing location for breeding or use of GM animals to the list of Proposed Lab Work Locations in Safety section 7a)i.

A job aid for submission of an IBC application to account for the use of genetically modified rodents is available. Please send requests to ibc@umn.edu.